Assay Detail
Functional
CHEMBL710838
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Tested for anti-HIV -1 Activity in MT-4 cell culture
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
S-Acyl-2-thioethyl aryl phosphotriester derivatives as mononucleotide prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.07 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.82 |
| CHEMBL141650 | — | — | 1 | 7.48 |
| CHEMBL336008 | — | — | 1 | 7.38 |
| CHEMBL342461 | — | — | 1 | 6.60 |
| CHEMBL291344 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL141650 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL336008 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL342461 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL291344 | — | EC50 | = | 810.0 | nM | 6.09 |