Assay Detail
Functional
CHEMBL710893
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative effect of compound on LNcaP cell line expressing wild-type p53
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A novel atypical retinoid endowed with proapoptotic and antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.71 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442016 | ADAROTENE | — | 1 | 6.92 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442016 | ADAROTENE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | IC50 | = | 320.0 | nM | 6.50 |