Assay Detail
Binding
CHEMBL710972
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Inhibition of human fibroblast collagenase, matrix metalloprotease-1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Hydroxamate inhibitors of the matrix metallo-proteinases (MMPs) containing novel P1 heteroatom based modifications
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.35 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410259 | — | — | 1 | 8.10 |
| CHEMBL59023 | — | — | 1 | 7.58 |
| CHEMBL87046 | — | — | 1 | 7.51 |
| CHEMBL86468 | — | — | 1 | 7.19 |
| CHEMBL86797 | — | — | 1 | 5.89 |
| CHEMBL87229 | — | — | 1 | 5.84 |
| CHEMBL313483 | — | — | 1 | 5.64 |
| CHEMBL85933 | — | — | 1 | 5.47 |
| CHEMBL85766 | — | — | 1 | 5.29 |
| CHEMBL430838 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410259 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL59023 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL87046 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL86468 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL86797 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL87229 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL313483 | — | Ki | = | 2270.0 | nM | 5.64 |
| CHEMBL85933 | — | Ki | = | 3350.0 | nM | 5.47 |
| CHEMBL85766 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL430838 | — | Ki | = | 9600.0 | nM | 5.02 |