Assay Detail
Functional
CHEMBL711295
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Negative logarithm of the molar concentration required to double the agonist concentration to achieve the original response in mu receptor from mouse vas deferens (MVD)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.86 | 9.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458631 | — | — | 1 | 9.25 |
| CHEMBL2375157 | — | — | 1 | 9.00 |
| CHEMBL607403 | — | — | 1 | 8.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458631 | — | Kd | = | 0.5623 | nM | 9.25 |
| CHEMBL2375157 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL607403 | — | Kd | = | 4.786 | nM | 8.32 |