Assay Detail
Functional
CHEMBL711296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative logarithm of the molar concentration required to produce 50% of the maximum effect in mu receptor from mouse vas deferens (MVD)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.40 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109390 | — | — | 1 | 9.90 |
| CHEMBL501451 | — | — | 1 | 8.52 |
| CHEMBL317956 | DELTORPHIN C | — | 1 | 7.90 |
| CHEMBL606737 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109390 | — | EC50 | = | 0.1259 | nM | 9.90 |
| CHEMBL501451 | — | EC50 | = | 3.02 | nM | 8.52 |
| CHEMBL317956 | DELTORPHIN C | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL606737 | — | EC50 | = | 52.48 | nM | 7.28 |