Assay Detail
Functional
CHEMBL711428
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Inhibitory activity against resistant HIV-1 strain MC639r was determined.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dihydro(alkylthio)(naphthylmethyl)oxopyrimidines: novel non-nucleoside reverse transcriptase inhibitors of the S-DABO series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.29 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.51 |
| CHEMBL417311 | — | — | 1 | 5.68 |
| CHEMBL290125 | — | — | 1 | 5.39 |
| CHEMBL33311 | — | — | 1 | 5.22 |
| CHEMBL286313 | — | — | 1 | 4.79 |
| CHEMBL287025 | — | — | 1 | 4.75 |
| CHEMBL32690 | — | — | 1 | 4.70 |
| CHEMBL284241 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL417311 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL290125 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL33311 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL286313 | — | EC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL287025 | — | EC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL32690 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL284241 | — | EC50 | > | 100000.0 | nM | - |