Assay Detail
Functional
CHEMBL711446
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Effective concentration required to achieve 50% inhibition of HIV-1 IIIB multiplication in hT4 lymphoblastoid MT-4 cells using MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of "AZT-HEPT", "AZT-pyridinone", and "ddC-HEPT" conjugates as inhibitors of HIV reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.73 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.70 |
| CHEMBL58213 | — | — | 1 | 6.48 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 5.62 |
| CHEMBL56328 | — | — | 1 | 5.37 |
| CHEMBL20610 | — | — | 1 | 5.21 |
| CHEMBL417953 | — | — | 1 | 4.00 |
| CHEMBL58914 | — | — | 1 | - |
| CHEMBL58891 | — | — | 1 | - |
| CHEMBL57161 | — | — | 1 | - |
| CHEMBL292392 | — | — | 1 | - |
| CHEMBL57313 | — | — | 1 | - |
| CHEMBL58653 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL58213 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL853 | ZALCITABINE | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL56328 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL20610 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL417953 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL58914 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL58891 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL57161 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL292392 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL57313 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL58653 | — | EC50 | > | 100000.0 | nM | - |