Assay Detail
Functional
CHEMBL711459
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Compound was evaluated for effective concentration required to achieve 50% protection of MT-4 cells against cytopathic effect of HIV-1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of novel inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.95 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37067 | — | — | 1 | 7.06 |
| CHEMBL37743 | — | — | 1 | 6.48 |
| CHEMBL31871 | HEPT | — | 1 | 5.19 |
| CHEMBL37833 | — | — | 1 | 5.06 |
| CHEMBL290413 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37067 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL37743 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL31871 | HEPT | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL37833 | — | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL290413 | — | EC50 | > | 250000.0 | nM | - |