Assay Detail
Functional
CHEMBL711464
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Compound was evaluated for the inhibition of HIV-1 induced cytopathic effect in MT-4 cells.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, enzymatic phosphorylation and antiviral activity of acyclic dienyl phosphonate derivatives of guanine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.33 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.40 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 4.89 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 4.70 |
| CHEMBL54579 | — | — | 1 | 4.31 |
| CHEMBL27200 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1460 | DIDANOSINE | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL484 | ADEFOVIR | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL54579 | — | EC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL27200 | — | EC50 | > | 100000.0 | nM | - |