Assay Detail
Functional
CHEMBL711606
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antitumor activity of compound against MCF-7 cell line (human breast cancer cells)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of OSW-1 analogs with modified side chains and their antitumor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.19 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443535 | — | — | 1 | 7.70 |
| CHEMBL327536 | — | — | 1 | 7.22 |
| CHEMBL262508 | — | — | 1 | 6.57 |
| CHEMBL92531 | — | — | 1 | 5.75 |
| CHEMBL96545 | — | — | 1 | 5.18 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443535 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL327536 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL262508 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL92531 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL96545 | — | IC50 | = | 6610.0 | nM | 5.18 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 18700.0 | nM | 4.73 |