Assay Detail
Functional
CHEMBL711622
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Antiviral potency was measured in HIV-1IIIb infected MT-4 human T-lymphoid cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.33 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18927 | — | — | 1 | 6.22 |
| CHEMBL19977 | — | — | 1 | 5.72 |
| CHEMBL20378 | — | — | 1 | 5.68 |
| CHEMBL20633 | — | — | 1 | 5.30 |
| CHEMBL20758 | — | — | 1 | 5.23 |
| CHEMBL20117 | — | — | 1 | 4.87 |
| CHEMBL20342 | — | — | 1 | 4.84 |
| CHEMBL278545 | — | — | 1 | 4.81 |
| CHEMBL20592 | — | — | 1 | - |
| CHEMBL20091 | — | — | 1 | - |
| CHEMBL20586 | — | — | 1 | - |
| CHEMBL20702 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18927 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL19977 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL20378 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL20633 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL20758 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL20117 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL20342 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL278545 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL20592 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL20091 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL20586 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL20702 | — | IC50 | > | 25000.0 | nM | - |