Assay Detail
Functional
CHEMBL711659
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AntiHIV-1 activity measured in MT-4 cells at 5 to 6 different concentrations, using the reverse transcriptase (RT) assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and anti-HIV-1 activity of 2'-"up"-fluoro analogues of active anti-AIDS nucleosides 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (DDC).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.78 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.35 |
| CHEMBL3350401 | — | — | 1 | 7.20 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 6.62 |
| CHEMBL3350402 | — | — | 1 | 6.15 |
| CHEMBL2448180 | — | — | 1 | 5.59 |
| CHEMBL2115404 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3350401 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL853 | ZALCITABINE | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3350402 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL2448180 | — | EC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL2115404 | — | EC50 | = | 103000.0 | nM | - |