Assay Detail
Functional
CHEMBL711662
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Antiviral activity was measured on HIV-1 in MT-4 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.62 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 7.75 |
| CHEMBL223807 | — | — | 1 | 7.68 |
| CHEMBL376065 | — | — | 1 | 7.55 |
| CHEMBL266136 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL991 | STAVUDINE | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL223807 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL376065 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL266136 | — | EC50 | = | 31.0 | nM | 7.51 |