Assay Detail
Functional
CHEMBL711758
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The compound was tested for intracellular cytotoxicity against MDA MB 361(mammary carcinoma cell line) expressing LacZ (beta-galactosidase).
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-361 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Self-immolative anthracycline prodrugs for suicide gene therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.12 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.92 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 7.77 |
| CHEMBL311606 | — | — | 1 | 6.95 |
| CHEMBL83801 | — | — | 1 | 6.94 |
| CHEMBL311697 | — | — | 1 | 6.59 |
| CHEMBL407383 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL311606 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL83801 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL311697 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL407383 | — | IC50 | = | 279.0 | nM | 6.55 |