Assay Detail
Functional
CHEMBL711840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective dose required to achieve protection of MT-4 cells from HIV-1 induced cytopathogenicity
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Computer-aided design, synthesis, and anti-HIV-1 activity in vitro of 2-alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as novel potent non-nucleoside reverse transcriptase inhibitors, also active against the Y181C variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.49 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL236161 | — | — | 1 | 8.22 |
| CHEMBL368172 | — | — | 1 | 7.70 |
| CHEMBL366402 | — | — | 1 | 7.70 |
| CHEMBL35033 | EMIVIRINE | 2.0 | 1 | 7.52 |
| CHEMBL309674 | — | — | 1 | 7.52 |
| CHEMBL177201 | — | — | 1 | 7.52 |
| CHEMBL309899 | — | — | 1 | 7.10 |
| CHEMBL312874 | — | — | 1 | 7.10 |
| CHEMBL173790 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL236161 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL368172 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL366402 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL35033 | EMIVIRINE | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL309674 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL177201 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL309899 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL312874 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL173790 | — | EC50 | = | 90.0 | nM | 7.05 |