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Assay Detail

CHEMBL711872

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity of compound against leishmania donovani was determined in luciferase assay
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Expert

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria.
Avery MA, Muraleedharan KM, Desai PV, Bandyopadhyaya AK, Furtado MM, Tekwani BL.
J Med Chem (2003) 46 : 4244 -4258
PubMed 13678403 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 67 4.85 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267345 AMPHOTERICIN B 4.0 1 8.00
CHEMBL336784 1 6.52
CHEMBL55 PENTAMIDINE 4.0 1 5.87
CHEMBL335299 1 5.85
CHEMBL134674 1 5.75
CHEMBL554867 1 5.72
CHEMBL335031 1 5.64
CHEMBL132641 1 5.54
CHEMBL135406 1 5.43
CHEMBL134479 1 5.43
CHEMBL135403 1 5.35
CHEMBL136952 1 5.33
CHEMBL130225 1 5.31
CHEMBL337225 1 5.12
CHEMBL334647 1 5.07
CHEMBL337455 1 4.96
CHEMBL135114 1 4.96
CHEMBL336733 1 4.94
CHEMBL135951 1 4.92
CHEMBL341199 1 4.92
CHEMBL336343 1 4.91
CHEMBL99340 1 4.90
CHEMBL1213590 1 4.84
CHEMBL337614 1 4.82
CHEMBL335105 1 4.78
CHEMBL132814 1 4.78
CHEMBL423164 1 4.76
CHEMBL335190 1 4.75
CHEMBL136006 1 4.59
CHEMBL335298 1 4.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267345 AMPHOTERICIN B IC50 = 10.0 nM 8.00
CHEMBL336784 IC50 = 300.0 nM 6.52
CHEMBL55 PENTAMIDINE IC50 = 1350.0 nM 5.87
CHEMBL335299 IC50 = 1400.0 nM 5.85
CHEMBL134674 IC50 = 1800.0 nM 5.75
CHEMBL554867 IC50 = 1900.0 nM 5.72
CHEMBL335031 IC50 = 2300.0 nM 5.64
CHEMBL132641 IC50 = 2900.0 nM 5.54
CHEMBL135406 IC50 = 3700.0 nM 5.43
CHEMBL134479 IC50 = 3700.0 nM 5.43
CHEMBL135403 IC50 = 4500.0 nM 5.35
CHEMBL136952 IC50 = 4700.0 nM 5.33
CHEMBL130225 IC50 = 4900.0 nM 5.31
CHEMBL337225 IC50 = 7500.0 nM 5.12
CHEMBL334647 IC50 = 8500.0 nM 5.07
CHEMBL337455 IC50 = 11000.0 nM 4.96
CHEMBL135114 IC50 = 11100.0 nM 4.96
CHEMBL336733 IC50 = 11600.0 nM 4.94
CHEMBL135951 IC50 = 11900.0 nM 4.92
CHEMBL341199 IC50 = 12000.0 nM 4.92
CHEMBL336343 IC50 = 12300.0 nM 4.91
CHEMBL99340 IC50 = 12600.0 nM 4.90
CHEMBL1213590 IC50 = 14400.0 nM 4.84
CHEMBL337614 IC50 = 15300.0 nM 4.82
CHEMBL132814 IC50 = 16800.0 nM 4.78
CHEMBL335105 IC50 = 16600.0 nM 4.78
CHEMBL423164 IC50 = 17400.0 nM 4.76
CHEMBL335190 IC50 = 17800.0 nM 4.75
CHEMBL136006 IC50 = 25500.0 nM 4.59
CHEMBL335298 IC50 = 26300.0 nM 4.58
CHEMBL336506 IC50 = 27500.0 nM 4.56
CHEMBL335083 IC50 = 31000.0 nM 4.51
CHEMBL339857 IC50 = 32300.0 nM 4.49
CHEMBL336114 IC50 = 33000.0 nM 4.48
CHEMBL421917 IC50 = 35500.0 nM 4.45
CHEMBL539296 IC50 = 36000.0 nM 4.44
CHEMBL133958 IC50 = 37700.0 nM 4.42
CHEMBL337399 IC50 = 38900.0 nM 4.41
CHEMBL342166 IC50 = 40500.0 nM 4.39
CHEMBL132436 IC50 = 40300.0 nM 4.39
CHEMBL1213589 IC50 = 44700.0 nM 4.35
CHEMBL135194 IC50 = 44400.0 nM 4.35
CHEMBL341399 IC50 = 44500.0 nM 4.35
CHEMBL341453 IC50 = 44800.0 nM 4.35
CHEMBL336090 IC50 = 45300.0 nM 4.34
CHEMBL2367467 DEOXOARTEMISININ IC50 = 46600.0 nM 4.33
CHEMBL133878 IC50 = 49200.0 nM 4.31
CHEMBL135805 IC50 = 49700.0 nM 4.30
CHEMBL335495 IC50 = 53800.0 nM 4.27
CHEMBL423716 IC50 = 56000.0 nM 4.25