Assay Detail
Binding
CHEMBL711897
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against recombinant human LAR using fluorescein diphosphate (FDP) as a substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein phosphatase F (CHEMBL3521) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.20 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51447 | — | — | 1 | 5.60 |
| CHEMBL301254 | — | — | 1 | 5.15 |
| CHEMBL58737 | — | — | 1 | 5.05 |
| CHEMBL60707 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51447 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL301254 | — | IC50 | = | 7090.0 | nM | 5.15 |
| CHEMBL58737 | — | IC50 | = | 8990.0 | nM | 5.05 |
| CHEMBL60707 | — | IC50 | = | 10200.0 | nM | 4.99 |