Assay Detail
Functional
CHEMBL711998
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective dose to achieve 50% protection of MT-4 cells from acutely infected HIV-1 strain IIIB
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Decomposition pathways and in vitro HIV inhibitory effects of isoddA pronucleotides: toward a rational approach for intracellular delivery of nucleoside 5'-monophosphates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.90 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.30 |
| CHEMBL291344 | — | — | 1 | 8.05 |
| CHEMBL60734 | — | — | 1 | 7.05 |
| CHEMBL60203 | — | — | 1 | 7.00 |
| CHEMBL433480 | — | — | 1 | 6.92 |
| CHEMBL293201 | — | — | 1 | 6.66 |
| CHEMBL439750 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL291344 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL60734 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL60203 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL433480 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL293201 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL439750 | — | EC50 | = | 45000.0 | nM | 4.35 |