Assay Detail
Functional
CHEMBL712000
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Efavirenz resistant HIV-1 (K103N-Y181C) induced cytopathicity in MT-4 cells.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Simple, short peptide derivatives of a sulfonylindolecarboxamide (L-737,126) active in vitro against HIV-1 wild type and variants carrying non-nucleoside reverse transcriptase inhibitor resistance mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 5.67 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.82 |
| CHEMBL85059 | — | — | 1 | 6.22 |
| CHEMBL127012 | — | — | 1 | 6.16 |
| CHEMBL126603 | — | — | 1 | 6.10 |
| CHEMBL126278 | — | — | 1 | 5.92 |
| CHEMBL127048 | — | — | 1 | 5.70 |
| CHEMBL2370619 | — | — | 1 | 5.66 |
| CHEMBL129797 | — | — | 1 | 5.55 |
| CHEMBL2370614 | — | — | 1 | 5.46 |
| CHEMBL129707 | — | — | 1 | 5.33 |
| CHEMBL2370613 | — | — | 1 | 5.28 |
| CHEMBL340564 | — | — | 1 | 5.22 |
| CHEMBL283950 | L-737126 | — | 1 | 5.10 |
| CHEMBL443548 | — | — | 1 | 4.80 |
| CHEMBL81097 | — | — | 1 | - |
| CHEMBL129046 | — | — | 1 | - |
| CHEMBL338559 | — | — | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL85059 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL127012 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL126603 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL126278 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL127048 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2370619 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL129797 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2370614 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL129707 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2370613 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL340564 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL283950 | L-737126 | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL443548 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL81097 | — | EC50 | >= | 100000.0 | nM | - |
| CHEMBL129046 | — | EC50 | > | 11000.0 | nM | - |
| CHEMBL338559 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 30000.0 | nM | - |