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Assay Detail

CHEMBL712246

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Functional
Inhibitory activity against LAI strain of HIV-I in MT-4 cell was determined
ChEMBL ↗
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues.
Ludovici DW, Kavash RW, Kukla MJ, Ho CY, Ye H, De Corte BL, Andries K, de Béthune MP, Azijn H, Pauwels R, Moereels HE, Heeres J, Koymans LM, de Jonge MR, Van Aken KJ, Daeyaert FF, Lewi PJ, Das K, Arnold E, Janssen PA.
Bioorg Med Chem Lett (2001) 11 : 2229 -2234
PubMed 11527704 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 59 7.94 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL71728 — — 1 9.52
CHEMBL72529 — — 1 9.30
CHEMBL306385 — — 1 9.22
CHEMBL73008 — — 1 9.22
CHEMBL304055 — — 1 9.10
CHEMBL305838 — — 1 9.00
CHEMBL71521 — — 1 9.00
CHEMBL74174 — — 1 9.00
CHEMBL74410 — — 1 8.92
CHEMBL302542 — — 1 8.89
CHEMBL71684 — — 1 8.85
CHEMBL302791 — — 1 8.82
CHEMBL431572 — — 1 8.70
CHEMBL70468 — — 1 8.70
CHEMBL69503 — — 1 8.70
CHEMBL73044 — — 1 8.68
CHEMBL70374 — — 1 8.62
CHEMBL71683 — — 1 8.62
CHEMBL73673 — — 1 8.60
CHEMBL73250 — — 1 8.57
CHEMBL73939 — — 1 8.54
CHEMBL72289 — — 1 8.52
CHEMBL421114 — — 1 8.51
CHEMBL70967 — — 1 8.51
CHEMBL74409 — — 1 8.51
CHEMBL71659 — — 1 8.46
CHEMBL302551 — — 1 8.40
CHEMBL307865 — — 1 8.34
CHEMBL306023 — — 1 8.30
CHEMBL72459 — — 1 8.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL71728 — IC50 = 0.3 nM 9.52
CHEMBL72529 — IC50 = 0.5 nM 9.30
CHEMBL73008 — IC50 = 0.6 nM 9.22
CHEMBL306385 — IC50 = 0.6 nM 9.22
CHEMBL304055 — IC50 = 0.8 nM 9.10
CHEMBL305838 — IC50 = 1.0 nM 9.00
CHEMBL71521 — IC50 = 1.0 nM 9.00
CHEMBL74174 — IC50 = 1.0 nM 9.00
CHEMBL74410 — IC50 = 1.2 nM 8.92
CHEMBL302542 — IC50 = 1.3 nM 8.89
CHEMBL71684 — IC50 = 1.4 nM 8.85
CHEMBL302791 — IC50 = 1.5 nM 8.82
CHEMBL69503 — IC50 = 2.0 nM 8.70
CHEMBL70468 — IC50 = 2.0 nM 8.70
CHEMBL431572 — IC50 = 2.0 nM 8.70
CHEMBL73044 — IC50 = 2.1 nM 8.68
CHEMBL70374 — IC50 = 2.4 nM 8.62
CHEMBL71683 — IC50 = 2.4 nM 8.62
CHEMBL73673 — IC50 = 2.5 nM 8.60
CHEMBL73250 — IC50 = 2.7 nM 8.57
CHEMBL73939 — IC50 = 2.9 nM 8.54
CHEMBL72289 — IC50 = 3.0 nM 8.52
CHEMBL421114 — IC50 = 3.1 nM 8.51
CHEMBL70967 — IC50 = 3.1 nM 8.51
CHEMBL74409 — IC50 = 3.1 nM 8.51
CHEMBL71659 — IC50 = 3.5 nM 8.46
CHEMBL302551 — IC50 = 4.0 nM 8.40
CHEMBL307865 — IC50 = 4.6 nM 8.34
CHEMBL306023 — IC50 = 5.0 nM 8.30
CHEMBL72459 — IC50 = 5.4 nM 8.27
CHEMBL310247 — IC50 = 5.5 nM 8.26
CHEMBL419252 — IC50 = 6.2 nM 8.21
CHEMBL307297 — IC50 = 6.3 nM 8.20
CHEMBL72059 — IC50 = 7.0 nM 8.15
CHEMBL305805 — IC50 = 7.3 nM 8.14
CHEMBL312080 — IC50 = 12.0 nM 7.92
CHEMBL71579 — IC50 = 12.0 nM 7.92
CHEMBL72343 — IC50 = 14.0 nM 7.85
CHEMBL71298 — IC50 = 14.0 nM 7.85
CHEMBL70613 — IC50 = 16.0 nM 7.80
CHEMBL70990 — IC50 = 18.0 nM 7.75
CHEMBL303226 — IC50 = 30.0 nM 7.52
CHEMBL268935 — IC50 = 31.0 nM 7.51
CHEMBL307474 — IC50 = 51.0 nM 7.29
CHEMBL70559 — IC50 = 86.0 nM 7.07
CHEMBL70745 — IC50 = 91.0 nM 7.04
CHEMBL70683 — IC50 = 94.0 nM 7.03
CHEMBL71750 — IC50 = 130.0 nM 6.89
CHEMBL74003 — IC50 = 160.0 nM 6.80
CHEMBL421492 — IC50 = 166.0 nM 6.78