Assay Detail
Functional
CHEMBL712251
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV-1 replication in infected MT-4 human T-lymphoid cells.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | T-lymphoid |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Nonpeptidal P2 ligands for HIV protease inhibitors: structure-based design, synthesis, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.47 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113233 | — | — | 1 | 8.92 |
| CHEMBL315403 | — | — | 1 | 8.74 |
| CHEMBL111945 | — | — | 1 | 8.39 |
| CHEMBL264397 | — | — | 1 | 8.38 |
| CHEMBL83768 | — | — | 1 | 8.19 |
| CHEMBL113090 | — | — | 1 | 7.77 |
| CHEMBL323950 | — | — | 1 | 7.74 |
| CHEMBL324223 | — | — | 1 | 7.71 |
| CHEMBL323752 | — | — | 1 | 7.62 |
| CHEMBL432066 | — | — | 1 | 7.57 |
| CHEMBL273317 | — | — | 1 | 7.12 |
| CHEMBL18389 | — | — | 1 | 6.88 |
| CHEMBL277725 | — | — | 1 | 6.88 |
| CHEMBL331599 | — | — | 1 | 6.72 |
| CHEMBL326258 | — | — | 1 | 6.39 |
| CHEMBL99213 | — | — | 1 | 6.16 |
| CHEMBL109273 | — | — | 1 | 5.77 |
| CHEMBL105753 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113233 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL315403 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL111945 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL264397 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL83768 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL113090 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL323950 | — | IC50 | = | 18.1 | nM | 7.74 |
| CHEMBL324223 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL323752 | — | IC50 | = | 23.8 | nM | 7.62 |
| CHEMBL432066 | — | IC50 | = | 27.1 | nM | 7.57 |
| CHEMBL273317 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL18389 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL277725 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL331599 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL326258 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL99213 | — | IC50 | = | 694.0 | nM | 6.16 |
| CHEMBL109273 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL105753 | — | IC50 | > | 3000.0 | nM | - |