Assay Detail
Functional
CHEMBL712255
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Compound was evaluated for its antiviral inhibition in MT-4 cell culture
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel inhibitors of HIV protease: design, synthesis and biological evaluation of picomolar inhibitors containing cyclic P1/P2 scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.80 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 7.70 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 7.40 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 7.30 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.00 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 6.68 |
| CHEMBL279869 | — | — | 1 | 6.52 |
| CHEMBL263072 | — | — | 2 | 6.52 |
| CHEMBL262204 | — | — | 1 | 6.52 |
| CHEMBL278928 | — | — | 1 | 5.82 |
| CHEMBL279397 | — | — | 1 | - |
| CHEMBL16167 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5483011 | INDINAVIR | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL116 | AMPRENAVIR | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL163 | RITONAVIR | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL279869 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL263072 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL263072 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL262204 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL278928 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL279397 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL16167 | — | IC50 | > | 50000.0 | nM | - |