Assay Detail
Binding
CHEMBL712301
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli S-adenosyl homocysteine/methylthioadenosine nucleosidase (MTA/SAH nucleosidase)
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (CHEMBL1250346) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli O157:H7 |
Publication
Structure-based design, synthesis, and antimicrobial activity of indazole-derived SAH/MTA nucleosidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 6.59 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL154234 | — | — | 1 | 8.80 |
| CHEMBL349317 | — | — | 1 | 8.47 |
| CHEMBL154218 | — | — | 1 | 8.41 |
| CHEMBL345254 | — | — | 1 | 8.09 |
| CHEMBL156794 | — | — | 1 | 7.97 |
| CHEMBL349792 | — | — | 1 | 7.96 |
| CHEMBL156734 | — | — | 1 | 7.90 |
| CHEMBL421824 | — | — | 1 | 7.89 |
| CHEMBL154219 | — | — | 1 | 7.84 |
| CHEMBL153941 | — | — | 1 | 7.77 |
| CHEMBL157262 | — | — | 1 | 7.70 |
| CHEMBL152127 | — | — | 1 | 7.60 |
| CHEMBL346924 | — | — | 1 | 7.54 |
| CHEMBL153876 | — | — | 1 | 7.44 |
| CHEMBL154684 | — | — | 1 | 7.44 |
| CHEMBL154614 | — | — | 1 | 7.28 |
| CHEMBL157317 | — | — | 1 | 7.03 |
| CHEMBL347675 | — | — | 1 | 7.00 |
| CHEMBL347181 | — | — | 1 | 6.90 |
| CHEMBL153820 | — | — | 1 | 6.72 |
| CHEMBL157223 | — | — | 1 | 6.62 |
| CHEMBL154601 | — | — | 1 | 6.30 |
| CHEMBL153309 | — | — | 1 | 6.30 |
| CHEMBL349108 | — | — | 1 | 6.12 |
| CHEMBL152983 | — | — | 1 | 6.00 |
| CHEMBL435874 | — | — | 1 | 5.92 |
| CHEMBL153833 | — | — | 1 | 5.75 |
| CHEMBL356233 | — | — | 1 | 5.66 |
| CHEMBL154404 | — | — | 1 | 5.64 |
| CHEMBL156955 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL154234 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL349317 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL154218 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL345254 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL156794 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL349792 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL156734 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL421824 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL154219 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL153941 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL157262 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL152127 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL346924 | — | Ki | = | 28.5 | nM | 7.54 |
| CHEMBL153876 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL154684 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL154614 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL157317 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL347675 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL347181 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL153820 | — | Ki | = | 191.0 | nM | 6.72 |
| CHEMBL157223 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL153309 | — | Ki | = | 498.0 | nM | 6.30 |
| CHEMBL154601 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL349108 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL152983 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL435874 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL153833 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL356233 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL154404 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL156955 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL153892 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL152399 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL421978 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL348866 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL157165 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL345702 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL424146 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL346894 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL440362 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL347925 | — | Ki | = | 64000.0 | nM | 4.19 |