Assay Detail
Functional
CHEMBL712346
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required for 50% protection of MT-4 cells against the cytopathic effect of HIV-1
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 41 | 7.06 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39015 | — | — | 1 | 8.57 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.52 |
| CHEMBL291926 | — | — | 1 | 8.49 |
| CHEMBL337338 | — | — | 1 | 8.36 |
| CHEMBL135589 | — | — | 1 | 8.27 |
| CHEMBL288688 | — | — | 1 | 8.23 |
| CHEMBL133035 | — | — | 1 | 8.17 |
| CHEMBL135497 | — | — | 1 | 8.16 |
| CHEMBL336762 | — | — | 1 | 8.13 |
| CHEMBL134403 | — | — | 1 | 8.11 |
| CHEMBL38711 | — | — | 1 | 7.92 |
| CHEMBL336388 | — | — | 1 | 7.92 |
| CHEMBL340049 | — | — | 1 | 7.89 |
| CHEMBL133036 | — | — | 1 | 7.85 |
| CHEMBL36995 | — | — | 1 | 7.72 |
| CHEMBL422622 | — | — | 1 | 7.58 |
| CHEMBL135444 | — | — | 1 | 7.11 |
| CHEMBL37067 | — | — | 1 | 7.06 |
| CHEMBL335584 | — | — | 1 | 7.02 |
| CHEMBL132977 | — | — | 1 | 7.02 |
| CHEMBL39093 | — | — | 1 | 7.00 |
| CHEMBL135996 | — | — | 1 | 6.66 |
| CHEMBL37743 | — | — | 1 | 6.48 |
| CHEMBL143258 | — | — | 1 | 6.47 |
| CHEMBL135690 | — | — | 1 | 6.46 |
| CHEMBL132865 | — | — | 1 | 6.35 |
| CHEMBL288728 | — | — | 1 | 5.92 |
| CHEMBL336577 | — | — | 1 | 5.80 |
| CHEMBL39047 | — | — | 1 | 5.68 |
| CHEMBL38768 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39015 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL291926 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL337338 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL135589 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL288688 | — | EC50 | = | 5.9 | nM | 8.23 |
| CHEMBL133035 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL135497 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL336762 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL134403 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL336388 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL38711 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL340049 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL133036 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL36995 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL422622 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL135444 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL37067 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL335584 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL132977 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL39093 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL135996 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL37743 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL143258 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL135690 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL132865 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL288728 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL336577 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL39047 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL38768 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL40091 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL343948 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL142271 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL31871 | HEPT | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL37833 | — | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL36719 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL142593 | — | EC50 | > | 55000.0 | nM | - |
| CHEMBL290413 | — | EC50 | > | 250000.0 | nM | - |
| CHEMBL356884 | — | EC50 | > | 32000.0 | nM | - |
| CHEMBL290685 | — | EC50 | > | 150000.0 | nM | - |
| CHEMBL135277 | — | EC50 | > | 91.0 | nM | - |