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Assay Detail

CHEMBL712362

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Tested for inhibition of cytopathic effect of HIV-2ROD in MT-4 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MT4
Confidence 1 — Organism
Curated By Intermediate

Target

MT4 (CHEMBL388)
Type CELL-LINE
Organism Homo sapiens

Publication

Anti-HIV activity of a series of cosalane amino acid conjugates.
Santhosh KC, De Clercq E, Pannecouque C, Witvrouw M, Loftus TL, Turpin JA, Buckheit RW, Cushman M.
Bioorg Med Chem Lett (2000) 10 : 2505 -2508
PubMed 11086716 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 10 4.55 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3138187 1 5.40
CHEMBL3138374 1 4.14
CHEMBL3138360 1 4.12
CHEMBL3137850 1 -
CHEMBL3138117 1 -
CHEMBL3138122 1 -
CHEMBL3138094 1 -
CHEMBL3137855 1 -
CHEMBL3137853 1 -
CHEMBL3137848 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3138187 EC50 = 4000.0 nM 5.40
CHEMBL3138374 EC50 = 71600.0 nM 4.14
CHEMBL3138360 EC50 = 75200.0 nM 4.12
CHEMBL3137850 EC50 > 125000.0 nM -
CHEMBL3138117 EC50 = 122000.0 nM -
CHEMBL3138122 EC50 > 62000.0 nM -
CHEMBL3138094 EC50 > 125000.0 nM -
CHEMBL3137855 EC50 > 125000.0 nM -
CHEMBL3137853 EC50 = 120000.0 nM -
CHEMBL3137848 EC50 > 125000.0 nM -