Assay Detail
Functional
CHEMBL712397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to protect the virus infected cells against viral cytopathicity was measured on HIV-1(IIIB) virus strain in MT-4 cells
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 42 | 6.79 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2373140 | — | — | 1 | 8.48 |
| CHEMBL1788331 | — | — | 1 | 8.38 |
| CHEMBL1788333 | — | — | 1 | 8.24 |
| CHEMBL1743684 | — | — | 1 | 8.21 |
| CHEMBL1788349 | — | — | 1 | 8.19 |
| CHEMBL1788332 | — | — | 1 | 8.10 |
| CHEMBL122487 | — | — | 1 | 8.10 |
| CHEMBL1788348 | — | — | 1 | 7.97 |
| CHEMBL124142 | 1,1'-[1,4-phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane]copper Heptahydrate (7H2O) | — | 1 | 7.74 |
| CHEMBL1788344 | — | — | 1 | 7.60 |
| CHEMBL1788330 | — | — | 1 | 7.47 |
| CHEMBL1788335 | — | — | 1 | 7.46 |
| CHEMBL1788352 | — | — | 1 | 7.39 |
| CHEMBL1788338 | — | — | 1 | 7.39 |
| CHEMBL1743680 | — | — | 1 | 7.26 |
| CHEMBL1788334 | — | — | 1 | 7.19 |
| CHEMBL1743683 | — | — | 1 | 7.12 |
| CHEMBL122048 | — | — | 1 | 7.07 |
| CHEMBL1788346 | — | — | 1 | 7.07 |
| CHEMBL1743677 | — | — | 1 | 6.97 |
| CHEMBL1788347 | — | — | 1 | 6.86 |
| CHEMBL1743679 | — | — | 1 | 6.80 |
| CHEMBL1788345 | — | — | 1 | 6.78 |
| CHEMBL1788339 | — | — | 1 | 6.69 |
| CHEMBL332659 | — | — | 1 | 6.50 |
| CHEMBL1743681 | — | — | 1 | 6.49 |
| CHEMBL1743685 | — | — | 1 | 6.49 |
| CHEMBL121707 | — | — | 1 | 6.43 |
| CHEMBL1788350 | — | — | 1 | 6.39 |
| CHEMBL1788336 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2373140 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1788331 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1788333 | — | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL1743684 | — | EC50 | = | 6.1 | nM | 8.21 |
| CHEMBL1788349 | — | EC50 | = | 6.4 | nM | 8.19 |
| CHEMBL1788332 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL122487 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL1788348 | — | EC50 | = | 10.7 | nM | 7.97 |
| CHEMBL124142 | 1,1'-[1,4-phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane]copper Heptahydrate (7H2O) | EC50 | = | 18.1 | nM | 7.74 |
| CHEMBL1788344 | — | EC50 | = | 25.3 | nM | 7.60 |
| CHEMBL1788330 | — | EC50 | = | 33.7 | nM | 7.47 |
| CHEMBL1788335 | — | EC50 | = | 34.7 | nM | 7.46 |
| CHEMBL1788352 | — | EC50 | = | 40.8 | nM | 7.39 |
| CHEMBL1788338 | — | EC50 | = | 40.6 | nM | 7.39 |
| CHEMBL1743680 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1788334 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1743683 | — | EC50 | = | 75.1 | nM | 7.12 |
| CHEMBL122048 | — | EC50 | = | 84.3 | nM | 7.07 |
| CHEMBL1788346 | — | EC50 | = | 84.5 | nM | 7.07 |
| CHEMBL1743677 | — | EC50 | = | 106.2 | nM | 6.97 |
| CHEMBL1788347 | — | EC50 | = | 138.3 | nM | 6.86 |
| CHEMBL1743679 | — | EC50 | = | 157.2 | nM | 6.80 |
| CHEMBL1788345 | — | EC50 | = | 166.8 | nM | 6.78 |
| CHEMBL1788339 | — | EC50 | = | 206.0 | nM | 6.69 |
| CHEMBL332659 | — | EC50 | = | 317.7 | nM | 6.50 |
| CHEMBL1743681 | — | EC50 | = | 321.8 | nM | 6.49 |
| CHEMBL1743685 | — | EC50 | = | 322.6 | nM | 6.49 |
| CHEMBL121707 | — | EC50 | = | 373.0 | nM | 6.43 |
| CHEMBL1788350 | — | EC50 | = | 402.5 | nM | 6.39 |
| CHEMBL1788336 | — | EC50 | = | 505.9 | nM | 6.30 |
| CHEMBL1788337 | — | EC50 | = | 528.7 | nM | 6.28 |
| CHEMBL1788343 | — | EC50 | = | 1357.4 | nM | 5.87 |
| CHEMBL122226 | — | EC50 | = | 1416.9 | nM | 5.85 |
| CHEMBL1743682 | — | EC50 | = | 1671.4 | nM | 5.78 |
| CHEMBL341527 | — | EC50 | = | 2433.6 | nM | 5.61 |
| CHEMBL1788342 | — | EC50 | = | 2724.7 | nM | 5.57 |
| CHEMBL1788351 | — | EC50 | = | 7794.7 | nM | 5.11 |
| CHEMBL1788341 | — | EC50 | = | 9130.1 | nM | 5.04 |
| CHEMBL1743678 | — | EC50 | = | 14852.0 | nM | 4.83 |
| CHEMBL1788340 | — | EC50 | = | 16739.0 | nM | 4.78 |
| CHEMBL369450 | 1,1'-[1,4-phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane] Palladium Diperchlorate Tetrahydrate (4H2O) | EC50 | = | 31548.0 | nM | 4.50 |
| CHEMBL125150 | — | EC50 | = | 399000.0 | nM | - |