Assay Detail
Functional
CHEMBL712399
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dose required to achieve 50% protection of MT-4 cells from HIV-1(IIIB) induced cytopathogenicity, determined by MIT method.
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit human immunodeficiency virus type 1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 40 | 5.96 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 9.15 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.52 |
| CHEMBL130390 | — | — | 1 | 7.30 |
| CHEMBL129949 | — | — | 1 | 7.05 |
| CHEMBL337392 | — | — | 1 | 7.05 |
| CHEMBL133626 | — | — | 1 | 7.00 |
| CHEMBL336723 | — | — | 1 | 7.00 |
| CHEMBL337668 | — | — | 1 | 6.70 |
| CHEMBL131152 | — | — | 1 | 6.52 |
| CHEMBL133052 | — | — | 1 | 6.40 |
| CHEMBL132556 | — | — | 1 | 6.10 |
| CHEMBL132150 | — | — | 1 | 6.05 |
| CHEMBL334614 | — | — | 1 | 6.00 |
| CHEMBL335321 | — | — | 1 | 5.96 |
| CHEMBL133478 | — | — | 1 | 5.85 |
| CHEMBL336513 | — | — | 1 | 5.68 |
| CHEMBL336622 | — | — | 1 | 5.66 |
| CHEMBL133679 | — | — | 1 | 5.60 |
| CHEMBL435395 | — | — | 1 | 5.57 |
| CHEMBL131848 | — | — | 1 | 5.52 |
| CHEMBL334862 | — | — | 1 | 5.44 |
| CHEMBL132792 | — | — | 1 | 5.35 |
| CHEMBL337397 | — | — | 1 | 5.14 |
| CHEMBL424270 | — | — | 1 | 5.13 |
| CHEMBL133057 | — | — | 1 | 5.12 |
| CHEMBL335286 | — | — | 1 | 5.08 |
| CHEMBL424447 | — | — | 1 | 5.07 |
| CHEMBL130613 | — | — | 1 | 4.96 |
| CHEMBL130220 | — | — | 1 | 4.69 |
| CHEMBL334895 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL130390 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL129949 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL337392 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL133626 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL336723 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL337668 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL131152 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL133052 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL132556 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL132150 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL334614 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL335321 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL133478 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL336513 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL336622 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL133679 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL435395 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL131848 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL334862 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL132792 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL337397 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL424270 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL133057 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL335286 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL424447 | — | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL130613 | — | EC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL130220 | — | EC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL334895 | — | EC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL134199 | — | EC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL133277 | — | EC50 | > | 498500.0 | nM | - |
| CHEMBL336838 | — | EC50 | > | 417000.0 | nM | - |
| CHEMBL132132 | — | EC50 | > | 273000.0 | nM | - |
| CHEMBL133956 | — | EC50 | > | 320600.0 | nM | - |
| CHEMBL424626 | — | EC50 | > | 446300.0 | nM | - |
| CHEMBL133056 | — | EC50 | > | 527500.0 | nM | - |
| CHEMBL134034 | — | EC50 | > | 403000.0 | nM | - |
| CHEMBL134035 | — | EC50 | > | 811000.0 | nM | - |
| CHEMBL132831 | — | EC50 | > | 74100.0 | nM | - |