Assay Detail
Functional
CHEMBL712402
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against HIV-1(IIIB) replication in MT-4 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit human immunodeficiency virus replication. 2. Effect of heteroaromatic linkers on the activity of bicyclams.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.85 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18442 | PLERIXAFOR | 4.0 | 1 | 8.38 |
| CHEMBL1204109 | — | — | 1 | 7.61 |
| CHEMBL1202144 | — | — | 1 | 7.58 |
| CHEMBL1204110 | — | — | 1 | 7.50 |
| CHEMBL17211 | — | — | 1 | 7.47 |
| CHEMBL1202143 | — | — | 1 | 7.40 |
| CHEMBL277151 | — | — | 1 | 7.33 |
| CHEMBL278202 | — | — | 1 | 6.80 |
| CHEMBL417454 | — | — | 1 | 6.73 |
| CHEMBL275434 | — | — | 1 | 6.69 |
| CHEMBL18628 | — | — | 1 | 6.17 |
| CHEMBL1202145 | — | — | 1 | 6.04 |
| CHEMBL18154 | — | — | 1 | 5.42 |
| CHEMBL1202142 | — | — | 1 | 4.79 |
| CHEMBL18097 | — | — | 1 | - |
| CHEMBL1202423 | — | — | 1 | - |
| CHEMBL17589 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18442 | PLERIXAFOR | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1204109 | — | EC50 | = | 24.5 | nM | 7.61 |
| CHEMBL1202144 | — | EC50 | = | 26.1 | nM | 7.58 |
| CHEMBL1204110 | — | EC50 | = | 31.6 | nM | 7.50 |
| CHEMBL17211 | — | EC50 | = | 33.7 | nM | 7.47 |
| CHEMBL1202143 | — | EC50 | = | 39.8 | nM | 7.40 |
| CHEMBL277151 | — | EC50 | = | 46.8 | nM | 7.33 |
| CHEMBL278202 | — | EC50 | = | 157.2 | nM | 6.80 |
| CHEMBL417454 | — | EC50 | = | 186.9 | nM | 6.73 |
| CHEMBL275434 | — | EC50 | = | 206.0 | nM | 6.69 |
| CHEMBL18628 | — | EC50 | = | 682.5 | nM | 6.17 |
| CHEMBL1202145 | — | EC50 | = | 908.1 | nM | 6.04 |
| CHEMBL18154 | — | EC50 | = | 3771.6 | nM | 5.42 |
| CHEMBL1202142 | — | EC50 | = | 16367.0 | nM | 4.79 |
| CHEMBL18097 | — | EC50 | = | 203000.0 | nM | - |
| CHEMBL1202423 | — | EC50 | = | 138530.0 | nM | - |
| CHEMBL17589 | — | EC50 | = | 200300.0 | nM | - |