Assay Detail
Binding
CHEMBL712412
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The negative logarithm of the concentration of antagonist that inhibits 50% of the binding of 125 I-labeled leuprolide to the rat pituitary LHRH receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gonadotropin-releasing hormone receptor (CHEMBL3066) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The effect of NMeTyr5 substitution in luteinizing hormone-releasing hormone antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 10.41 | 10.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409219 | — | — | 1 | 10.87 |
| CHEMBL268397 | — | — | 1 | 10.63 |
| CHEMBL263839 | — | — | 1 | 10.50 |
| CHEMBL263840 | — | — | 1 | 10.48 |
| CHEMBL268319 | — | — | 1 | 10.28 |
| CHEMBL409990 | — | — | 1 | 10.21 |
| CHEMBL438829 | — | — | 1 | 9.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409219 | — | Ki | = | 0.01349 | nM | 10.87 |
| CHEMBL268397 | — | Ki | = | 0.02344 | nM | 10.63 |
| CHEMBL263839 | — | Ki | = | 0.03162 | nM | 10.50 |
| CHEMBL263840 | — | Ki | = | 0.03311 | nM | 10.48 |
| CHEMBL268319 | — | Ki | = | 0.05248 | nM | 10.28 |
| CHEMBL409990 | — | Ki | = | 0.06166 | nM | 10.21 |
| CHEMBL438829 | — | Ki | = | 0.1175 | nM | 9.93 |