Assay Detail
Binding
CHEMBL712505
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In vitro binding affinity to human luteinizing hormone-releasing hormone (LHRH) receptor cloned in CHO cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gonadotropin-releasing hormone receptor (CHEMBL1855) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Nonpeptide luteinizing hormone-releasing hormone antagonists derived from erythromycin A: design, synthesis, and biological activity of cladinose replacement analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.85 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12282 | — | — | 1 | 9.48 |
| CHEMBL303274 | — | — | 1 | 8.73 |
| CHEMBL275935 | — | — | 1 | 8.25 |
| CHEMBL273440 | — | — | 1 | 7.82 |
| CHEMBL275467 | — | — | 1 | 7.73 |
| CHEMBL273387 | — | — | 1 | 7.65 |
| CHEMBL267568 | — | — | 1 | 7.44 |
| CHEMBL273275 | — | — | 1 | 7.42 |
| CHEMBL429949 | — | — | 1 | 7.31 |
| CHEMBL412634 | — | — | 1 | 7.18 |
| CHEMBL273536 | — | — | 1 | 7.10 |
| CHEMBL273466 | — | — | 1 | 6.94 |
| CHEMBL268489 | — | — | 1 | 6.67 |
| CHEMBL276217 | — | — | 1 | 6.56 |
| CHEMBL430312 | — | — | 1 | 6.25 |
| CHEMBL428008 | — | — | 1 | 6.20 |
| CHEMBL275521 | — | — | 1 | 6.10 |
| CHEMBL12666 | — | — | 1 | 5.79 |
| CHEMBL268491 | — | — | 1 | 5.69 |
| CHEMBL12589 | — | — | 1 | 5.69 |
| CHEMBL416337 | — | — | 1 | 5.33 |
| CHEMBL275251 | — | — | 1 | 5.25 |
| CHEMBL12265 | — | — | 1 | 5.00 |
| CHEMBL273535 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12282 | — | Ki | = | 0.3311 | nM | 9.48 |
| CHEMBL303274 | — | Ki | = | 1.862 | nM | 8.73 |
| CHEMBL275935 | — | Ki | = | 5.623 | nM | 8.25 |
| CHEMBL273440 | — | Ki | = | 15.14 | nM | 7.82 |
| CHEMBL275467 | — | Ki | = | 18.62 | nM | 7.73 |
| CHEMBL273387 | — | Ki | = | 22.39 | nM | 7.65 |
| CHEMBL267568 | — | Ki | = | 36.31 | nM | 7.44 |
| CHEMBL273275 | — | Ki | = | 38.02 | nM | 7.42 |
| CHEMBL429949 | — | Ki | = | 48.98 | nM | 7.31 |
| CHEMBL412634 | — | Ki | = | 66.07 | nM | 7.18 |
| CHEMBL273536 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL273466 | — | Ki | = | 114.82 | nM | 6.94 |
| CHEMBL268489 | — | Ki | = | 213.8 | nM | 6.67 |
| CHEMBL276217 | — | Ki | = | 275.42 | nM | 6.56 |
| CHEMBL430312 | — | Ki | = | 562.34 | nM | 6.25 |
| CHEMBL428008 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL275521 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL12666 | — | Ki | = | 1621.81 | nM | 5.79 |
| CHEMBL268491 | — | Ki | = | 2041.74 | nM | 5.69 |
| CHEMBL12589 | — | Ki | = | 2041.74 | nM | 5.69 |
| CHEMBL416337 | — | Ki | = | 4677.35 | nM | 5.33 |
| CHEMBL275251 | — | Ki | = | 5623.41 | nM | 5.25 |
| CHEMBL12265 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL273535 | — | Ki | < | 100.0 | nM | - |