Assay Detail
Binding
CHEMBL712559
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In vitro inhibitory activity against matrix metalloprotease-9 (MMP-9)
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of piperazine-based matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 8.39 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333586 | — | — | 1 | 9.22 |
| CHEMBL123967 | — | — | 1 | 9.22 |
| CHEMBL125598 | — | — | 1 | 9.05 |
| CHEMBL124558 | — | — | 1 | 8.92 |
| CHEMBL331095 | — | — | 1 | 8.89 |
| CHEMBL123627 | — | — | 1 | 8.80 |
| CHEMBL123615 | — | — | 1 | 8.77 |
| CHEMBL332302 | — | — | 1 | 8.74 |
| CHEMBL340923 | — | — | 1 | 8.74 |
| CHEMBL332134 | — | — | 1 | 8.72 |
| CHEMBL338007 | — | — | 1 | 8.72 |
| CHEMBL126044 | — | — | 1 | 8.68 |
| CHEMBL125068 | — | — | 1 | 8.64 |
| CHEMBL339903 | — | — | 1 | 8.64 |
| CHEMBL123563 | — | — | 1 | 8.62 |
| CHEMBL124100 | — | — | 1 | 8.59 |
| CHEMBL421644 | — | — | 1 | 8.52 |
| CHEMBL338077 | — | — | 1 | 8.52 |
| CHEMBL125755 | — | — | 1 | 8.44 |
| CHEMBL127093 | — | — | 1 | 8.42 |
| CHEMBL419430 | — | — | 1 | 8.39 |
| CHEMBL123320 | — | — | 1 | 8.36 |
| CHEMBL338223 | — | — | 1 | 8.30 |
| CHEMBL123499 | — | — | 1 | 8.22 |
| CHEMBL126388 | — | — | 1 | 8.18 |
| CHEMBL124680 | — | — | 1 | 8.16 |
| CHEMBL124026 | — | — | 1 | 8.12 |
| CHEMBL125384 | — | — | 1 | 8.08 |
| CHEMBL124514 | — | — | 1 | 7.89 |
| CHEMBL124265 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333586 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL123967 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL125598 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL124558 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL331095 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL123627 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL123615 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL332302 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL340923 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL338007 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL332134 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL126044 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL125068 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL339903 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL123563 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL124100 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL421644 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL338077 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL125755 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL127093 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL419430 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL123320 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL338223 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL123499 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL126388 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL124680 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL124026 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL125384 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL124514 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL124265 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL338453 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL125601 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL419607 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL124681 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL435206 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL125281 | — | IC50 | = | 32.0 | nM | 7.50 |