Assay Detail
Binding
CHEMBL712567
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Inhibition of matrix metalloprotease-9, gelatinase-B
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.18 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16519 | — | — | 1 | 9.85 |
| CHEMBL16554 | — | — | 1 | 9.85 |
| CHEMBL16630 | — | — | 1 | 8.10 |
| CHEMBL16933 | — | — | 1 | 8.10 |
| CHEMBL16520 | RO-319790 | — | 1 | 7.92 |
| CHEMBL16650 | — | — | 1 | 7.92 |
| CHEMBL16595 | — | — | 1 | 7.70 |
| CHEMBL17082 | — | — | 1 | 7.62 |
| CHEMBL16505 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16519 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL16554 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL16630 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL16933 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL16520 | RO-319790 | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL16650 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL16595 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL17082 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL16505 | — | IC50 | = | 250.0 | nM | 6.60 |