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Assay Detail

CHEMBL712593

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphate.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Glycogen phosphorylase, liver form (CHEMBL2568)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase.
Hoover DJ, Lefkowitz-Snow S, Burgess-Henry JL, Martin WH, Armento SJ, Stock IA, McPherson RK, Genereux PE, Gibbs EM, Treadway JL.
J Med Chem (1998) 41 : 2934 -2938
PubMed 9685232 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 6.30 7.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL430503 1 7.09
CHEMBL329493 1 7.01
CHEMBL318910 1 6.96
CHEMBL319136 1 6.96
CHEMBL99379 1 6.96
CHEMBL100872 1 6.85
CHEMBL99597 1 6.77
CHEMBL99889 1 6.69
CHEMBL319854 1 6.68
CHEMBL98891 1 6.66
CHEMBL316598 1 6.58
CHEMBL317410 1 6.58
CHEMBL317861 1 6.48
CHEMBL319165 1 6.40
CHEMBL327504 1 6.37
CHEMBL99556 1 6.36
CHEMBL319152 1 6.17
CHEMBL323569 1 5.77
CHEMBL431463 1 5.77
CHEMBL98496 1 5.77
CHEMBL317026 1 5.75
CHEMBL101891 1 5.33
CHEMBL316488 1 5.19
CHEMBL319736 1 5.17
CHEMBL98283 1 5.06
CHEMBL98339 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL430503 IC50 = 82.0 nM 7.09
CHEMBL329493 IC50 = 97.0 nM 7.01
CHEMBL318910 IC50 = 110.0 nM 6.96
CHEMBL319136 IC50 = 110.0 nM 6.96
CHEMBL99379 IC50 = 110.0 nM 6.96
CHEMBL100872 IC50 = 140.0 nM 6.85
CHEMBL99597 IC50 = 170.0 nM 6.77
CHEMBL99889 IC50 = 205.0 nM 6.69
CHEMBL319854 IC50 = 210.0 nM 6.68
CHEMBL98891 IC50 = 220.0 nM 6.66
CHEMBL316598 IC50 = 260.0 nM 6.58
CHEMBL317410 IC50 = 260.0 nM 6.58
CHEMBL317861 IC50 = 330.0 nM 6.48
CHEMBL319165 IC50 = 400.0 nM 6.40
CHEMBL327504 IC50 = 430.0 nM 6.37
CHEMBL99556 IC50 = 440.0 nM 6.36
CHEMBL319152 IC50 = 680.0 nM 6.17
CHEMBL323569 IC50 = 1700.0 nM 5.77
CHEMBL431463 IC50 = 1700.0 nM 5.77
CHEMBL98496 IC50 = 1700.0 nM 5.77
CHEMBL317026 IC50 = 1800.0 nM 5.75
CHEMBL101891 IC50 = 4700.0 nM 5.33
CHEMBL316488 IC50 = 6500.0 nM 5.19
CHEMBL319736 IC50 = 6800.0 nM 5.17
CHEMBL98283 IC50 = 8700.0 nM 5.06
CHEMBL98339 IC50 > 10000.0 nM -