Assay Detail
Binding
CHEMBL712595
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In vitro inhibitory activity against human liver glycogen phosphorylase a (HLGPa)
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.48 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115651 | — | — | 1 | 8.70 |
| CHEMBL115341 | — | — | 1 | 8.40 |
| CHEMBL423509 | — | — | 1 | 8.30 |
| CHEMBL113762 | — | — | 1 | 8.10 |
| CHEMBL113736 | — | — | 1 | 8.10 |
| CHEMBL114226 | — | — | 1 | 8.04 |
| CHEMBL114731 | — | — | 1 | 7.96 |
| CHEMBL326950 | — | — | 1 | 7.96 |
| CHEMBL114846 | — | — | 1 | 7.91 |
| CHEMBL334272 | — | — | 1 | 7.89 |
| CHEMBL115441 | — | — | 1 | 7.82 |
| CHEMBL114950 | — | — | 1 | 7.41 |
| CHEMBL114271 | — | — | 1 | 7.37 |
| CHEMBL117483 | — | — | 1 | 7.19 |
| CHEMBL326810 | — | — | 1 | 7.10 |
| CHEMBL115395 | — | — | 1 | 6.98 |
| CHEMBL115045 | — | — | 1 | 6.96 |
| CHEMBL114858 | — | — | 1 | 6.40 |
| CHEMBL323707 | — | — | 1 | 6.16 |
| CHEMBL324357 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115651 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL115341 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL423509 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL113762 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL113736 | — | IC50 | = | 7.88 | nM | 8.10 |
| CHEMBL114226 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL114731 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL326950 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL114846 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL334272 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL115441 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL114950 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL114271 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL117483 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL326810 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL115395 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL115045 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL114858 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL323707 | — | IC50 | = | 692.0 | nM | 6.16 |
| CHEMBL324357 | — | IC50 | = | 15600.0 | nM | 4.81 |