Assay Detail
Binding
CHEMBL712745
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Binding affinity against human Melanocortin-4 receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.98 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2096742 | — | — | 1 | 10.22 |
| CHEMBL1161323 | — | — | 1 | 9.80 |
| CHEMBL1161313 | — | — | 1 | 9.64 |
| CHEMBL1161318 | — | — | 1 | 9.32 |
| CHEMBL358015 | — | — | 1 | 9.30 |
| CHEMBL1161316 | — | — | 1 | 9.29 |
| CHEMBL1161321 | — | — | 1 | 8.89 |
| CHEMBL415333 | — | — | 1 | 8.82 |
| CHEMBL2372588 | — | — | 1 | 8.46 |
| CHEMBL2372589 | — | — | 1 | 8.43 |
| CHEMBL1161320 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2096742 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL1161323 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL1161313 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL1161318 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL358015 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1161316 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL1161321 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL415333 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2372588 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL2372589 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1161320 | — | IC50 | = | 270.0 | nM | 6.57 |