Assay Detail
Binding
CHEMBL712801
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Concentration for half maximal activation of metabotropic glutamate mGluR6 in rat
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 6 (CHEMBL3842) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Metabotropic glutamate receptors: novel targets for drug development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.47 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33567 | — | — | 1 | 6.05 |
| CHEMBL284377 | DEXFOSFOSERINE | 2.0 | 1 | 5.57 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 4.80 |
| CHEMBL34453 | — | — | 1 | - |
| CHEMBL279956 | QUISQUALATE | — | 1 | - |
| CHEMBL30285 | IBOTENIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33567 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL284377 | DEXFOSFOSERINE | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL34453 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL279956 | QUISQUALATE | EC50 | = | 1000000.0 | nM | - |
| CHEMBL30285 | IBOTENIC ACID | EC50 | = | 1000000.0 | nM | - |