Assay Detail
Binding
CHEMBL712802
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Effect on Metabotropic glutamate receptor 6
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 6 (CHEMBL3842) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 4.82 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33567 | — | — | 1 | 6.24 |
| CHEMBL76232 | D-GLUTAMATE | — | 1 | 4.70 |
| CHEMBL315268 | — | — | 1 | 4.24 |
| CHEMBL107768 | — | — | 1 | 4.09 |
| CHEMBL1169505 | — | — | 1 | - |
| CHEMBL262416 | — | — | 1 | - |
| CHEMBL88804 | (S)-2-AMINOADIPIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33567 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL76232 | D-GLUTAMATE | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL315268 | — | EC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL107768 | — | EC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL1169505 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL262416 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL88804 | (S)-2-AMINOADIPIC ACID | EC50 | = | 140000.0 | nM | - |