Compound Detail
CHEMBL88804
(S)-2-AMINOADIPIC ACID Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL88804 |
| Name | (S)-2-AMINOADIPIC ACID |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OYIFNHCXNCRBQI-BYPYZUCNSA-N |
2
Targets
9
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
161.2
MW (Da)
-0.35
ALogP
3
HBA
3
HBD
100.6
PSA (Ų)
0.51
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 7 meas. best 4.46
Ki 2 meas. best 4.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 CHEMBL2851 | EC50 | 4.46 | 4.46 | 35000.0 | 2 |
| Metabotropic glutamate receptor 2 CHEMBL5137 | EC50 | 4.46 | 4.46 | 35000.0 | 2 |
| Metabotropic glutamate receptor 2 CHEMBL5137 | Ki | 4.46 | 4.46 | 35000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 | EC50 | = | 35000.0 | nM | 4.46 | Effect on Metabotropic glutamate receptor 2 | 9357538 |
| Metabotropic glutamate receptor 2 | EC50 | = | 35000.0 | nM | 4.46 | Agonistic activity at mGlu2 receptor expressed in CHO cells | 8759641 |
| Metabotropic glutamate receptor 2 | EC50 | = | 35000.0 | nM | 4.46 | Compound was evaluated for the inhibitory activity against cloned Metabotropic g... | 12213064 |
| Metabotropic glutamate receptor 2 | EC50 | = | 35000.0 | nM | 4.46 | Agonist activity at mGluR2 receptor (unknown origin) expressed in CHO cells | 38245976 |
| Metabotropic glutamate receptor 2 | Ki | = | 35000.0 | nM | 4.46 | Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2). | 10893301 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8759641 | 10.1021/jm9602569 | Metabotropic glutamate receptor 2 | 1 |
| 38245976 | 10.1016/j.ejmech.2024.116157 | Metabotropic glutamate receptor 6 | 1 |
| 38245976 | 10.1016/j.ejmech.2024.116157 | Metabotropic glutamate receptor 2 | 1 |
| 17417631 | 10.1038/nchembio873 | Unchecked | 1 |
| 15689171 | 10.1021/jm049365a | THP-1 | 1 |
| 12213064 | 10.1021/jm020122x | Metabotropic glutamate receptor 4 | 1 |
| 12213064 | 10.1021/jm020122x | Metabotropic glutamate receptor 2 | 1 |
| 12213064 | 10.1021/jm020122x | Metabotropic glutamate receptor 5 | 1 |
| 12213064 | 10.1021/jm020122x | Metabotropic glutamate receptor 1 | 1 |
| 8759641 | 10.1021/jm9602569 | Metabotropic glutamate receptor 6 | 1 |
| 8759641 | 10.1021/jm9602569 | Metabotropic glutamate receptor 4 | 1 |
| 9357538 | 10.1021/jm9703597 | Metabotropic glutamate receptor 1 | 1 |
| 8759641 | 10.1021/jm9602569 | Metabotropic glutamate receptor 1 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 6 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 5 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 4 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 2 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 1 | 1 |
| 9357538 | 10.1021/jm9703597 | Metabotropic glutamate receptor 6 | 1 |
| 9357538 | 10.1021/jm9703597 | Metabotropic glutamate receptor 4 | 1 |
Data from ChEMBL 36 via Core Engine