Assay Detail
Binding
CHEMBL718228
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 2 (CHEMBL2851) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.67 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 5.40 |
| CHEMBL88804 | (S)-2-AMINOADIPIC ACID | — | 1 | 4.46 |
| CHEMBL334842 | — | — | 1 | 4.43 |
| CHEMBL131922 | — | — | 1 | 4.40 |
| CHEMBL262416 | — | — | 1 | - |
| CHEMBL315268 | — | — | 1 | - |
| CHEMBL88184 | — | — | 1 | - |
| CHEMBL337075 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL88804 | (S)-2-AMINOADIPIC ACID | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL334842 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL131922 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL262416 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL315268 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL88184 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL337075 | — | EC50 | > | 1000000.0 | nM | - |