Compound Detail
CHEMBL334842
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Basic Information
| ChEMBL ID | CHEMBL334842 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AJASJCCJLLTPOF-GSVOUGTGSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
13
Publications
0
Known Names
Molecular Properties
203.2
MW (Da)
-0.41
ALogP
6
HBA
3
HBD
109.3
PSA (Ų)
0.61
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 4.43
IC50 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 CHEMBL2851 | EC50 | 4.43 | 4.43 | 37000.0 | 1 |
| Metabotropic glutamate receptor 2 CHEMBL5137 | EC50 | 4.43 | 4.43 | 37000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 | EC50 | = | 37000.0 | nM | 4.43 | Compound was evaluated for the inhibitory activity against cloned Metabotropic g... | 12213064 |
| Metabotropic glutamate receptor 2 | EC50 | = | 37000.0 | nM | 4.43 | Agonist activity at human mGluR2 receptor expressed in HEK cells | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1039/C1MD00186H | Unchecked | 2 |
| 12213064 | 10.1021/jm020122x | Metabotropic glutamate receptor 1 | 1 |
| 12213064 | 10.1021/jm020122x | Metabotropic glutamate receptor 5 | 1 |
| 12213064 | 10.1021/jm020122x | Metabotropic glutamate receptor 2 | 1 |
| 12213064 | 10.1021/jm020122x | Metabotropic glutamate receptor 4 | 1 |
| 12213064 | 10.1021/jm020122x | Protein lifeguard 1 | 1 |
| - | 10.1039/C1MD00186H | Metabotropic glutamate receptor 2 | 1 |
| - | 10.1039/C1MD00186H | Metabotropic glutamate receptor 1 | 1 |
| - | 10.1039/C1MD00186H | Glutamate NMDA receptor | 1 |
| - | 10.1039/C1MD00186H | Metabotropic glutamate receptor 7 | 1 |
| - | 10.1039/C1MD00186H | Metabotropic glutamate receptor 5 | 1 |
| - | 10.1039/C1MD00186H | Metabotropic glutamate receptor 4 | 1 |
| - | 10.1039/C1MD00186H | Metabotropic glutamate receptor 3 | 1 |
Data from ChEMBL 36 via Core Engine