Assay Detail
Functional
CHEMBL712877
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Viral cytopathicity against HIV -I (HTLV-IIIb) strain determined in MT-4 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.03 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3138187 | — | — | 1 | 5.75 |
| CHEMBL3138267 | — | — | 1 | 5.60 |
| CHEMBL113197 | — | — | 1 | 4.66 |
| CHEMBL3137943 | — | — | 1 | 4.57 |
| CHEMBL3138268 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3138187 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3138267 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL113197 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL3137943 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL3138268 | — | IC50 | = | 27700.0 | nM | 4.56 |