Assay Detail
Functional
CHEMBL712878
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for 50% protection of MT-4 cells against the cytopathic effect of HIV-1
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo-[4,5,1-jk][1,4]benzodiazepin- 2(1H)-one (TlBO) derivatives. 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.65 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354989 | — | — | 1 | 8.52 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.39 |
| CHEMBL58711 | TIVIRAPINE | 2.0 | 1 | 8.37 |
| CHEMBL351433 | — | — | 1 | 8.30 |
| CHEMBL58119 | — | — | 1 | 8.24 |
| CHEMBL59279 | — | — | 1 | 7.87 |
| CHEMBL59131 | — | — | 1 | 7.60 |
| CHEMBL293814 | — | — | 1 | 7.59 |
| CHEMBL58811 | — | — | 1 | 7.53 |
| CHEMBL293498 | — | — | 1 | 7.47 |
| CHEMBL433931 | — | — | 1 | 7.47 |
| CHEMBL58952 | — | — | 1 | 7.33 |
| CHEMBL352425 | — | — | 1 | 7.32 |
| CHEMBL58506 | — | — | 1 | 7.25 |
| CHEMBL167851 | — | — | 1 | 7.06 |
| CHEMBL423825 | — | — | 1 | 7.02 |
| CHEMBL58453 | — | — | 1 | 6.73 |
| CHEMBL167484 | — | — | 1 | 6.61 |
| CHEMBL168117 | — | — | 1 | 6.50 |
| CHEMBL298626 | — | — | 1 | 6.36 |
| CHEMBL291319 | — | — | 1 | 6.31 |
| CHEMBL58493 | — | — | 1 | 6.00 |
| CHEMBL432516 | — | — | 1 | 5.97 |
| CHEMBL293271 | — | — | 1 | 5.94 |
| CHEMBL60982 | — | — | 1 | 5.61 |
| CHEMBL353297 | — | — | 1 | 5.33 |
| CHEMBL59160 | — | — | 1 | 5.23 |
| CHEMBL167287 | — | — | 1 | 5.20 |
| CHEMBL166769 | — | — | 1 | 5.18 |
| CHEMBL349465 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354989 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL58711 | TIVIRAPINE | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL351433 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL58119 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL59279 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL59131 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL293814 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL58811 | — | IC50 | = | 29.6 | nM | 7.53 |
| CHEMBL293498 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL433931 | — | IC50 | = | 33.9 | nM | 7.47 |
| CHEMBL58952 | — | IC50 | = | 47.3 | nM | 7.33 |
| CHEMBL352425 | — | IC50 | = | 47.4 | nM | 7.32 |
| CHEMBL58506 | — | IC50 | = | 56.3 | nM | 7.25 |
| CHEMBL167851 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL423825 | — | IC50 | = | 95.9 | nM | 7.02 |
| CHEMBL58453 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL167484 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL168117 | — | IC50 | = | 314.2 | nM | 6.50 |
| CHEMBL298626 | — | IC50 | = | 437.6 | nM | 6.36 |
| CHEMBL291319 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL58493 | — | IC50 | = | 989.0 | nM | 6.00 |
| CHEMBL432516 | — | IC50 | = | 1075.0 | nM | 5.97 |
| CHEMBL293271 | — | IC50 | = | 1139.6 | nM | 5.94 |
| CHEMBL60982 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL353297 | — | IC50 | = | 4725.0 | nM | 5.33 |
| CHEMBL59160 | — | IC50 | = | 5919.0 | nM | 5.23 |
| CHEMBL167287 | — | IC50 | = | 6360.0 | nM | 5.20 |
| CHEMBL167459 | — | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL349465 | — | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL166769 | — | IC50 | = | 6630.0 | nM | 5.18 |
| CHEMBL291565 | — | IC50 | = | 33430.0 | nM | 4.48 |
| CHEMBL165335 | — | IC50 | = | 60550.0 | nM | 4.22 |
| CHEMBL355449 | — | IC50 | = | 596000.0 | nM | - |
| CHEMBL354229 | — | IC50 | = | 872000.0 | nM | - |
| CHEMBL165336 | — | IC50 | > | 796000.0 | nM | - |
| CHEMBL164233 | — | IC50 | = | 849000.0 | nM | - |
| CHEMBL167814 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL167270 | — | IC50 | > | 5940.0 | nM | - |
| CHEMBL352555 | — | IC50 | = | 159000.0 | nM | - |