Assay Detail
Functional
CHEMBL712882
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Antagonistic activity against metabotropic glutamate receptor 7 (mGluR7) was evaluated
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.04 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432038 | — | — | 1 | 6.00 |
| CHEMBL97200 | — | — | 1 | 5.58 |
| CHEMBL319732 | — | — | 1 | 5.20 |
| CHEMBL329920 | — | — | 1 | 5.12 |
| CHEMBL420262 | — | — | 1 | 5.11 |
| CHEMBL95868 | — | — | 1 | 5.03 |
| CHEMBL319279 | — | — | 1 | 4.81 |
| CHEMBL439775 | — | — | 1 | 4.71 |
| CHEMBL97574 | — | — | 1 | 4.64 |
| CHEMBL99462 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432038 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL97200 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL319732 | — | IC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL329920 | — | IC50 | = | 7610.0 | nM | 5.12 |
| CHEMBL420262 | — | IC50 | = | 7820.0 | nM | 5.11 |
| CHEMBL95868 | — | IC50 | = | 9420.0 | nM | 5.03 |
| CHEMBL319279 | — | IC50 | = | 15350.0 | nM | 4.81 |
| CHEMBL439775 | — | IC50 | = | 19660.0 | nM | 4.71 |
| CHEMBL97574 | — | IC50 | = | 23070.0 | nM | 4.64 |
| CHEMBL99462 | — | IC50 | = | 67820.0 | nM | 4.17 |