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Assay Detail

CHEMBL712892

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Beta-Lactamase Inhibition of metallo-beta-lactamase representative class B (L1) enzyme
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Beta-lactamase L1 (CHEMBL3326)
Type SINGLE PROTEIN
Organism Stenotrophomonas maltophilia

Publication

Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases.
Buynak JD, Chen H, Vogeti L, Gadhachanda VR, Buchanan CA, Palzkill T, Shaw RW, Spencer J, Walsh TR.
Bioorg Med Chem Lett (2004) 14 : 1299 -1304
PubMed 14980686 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.13 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL25766 1 7.00
CHEMBL24235 1 6.52
CHEMBL26275 1 5.12
CHEMBL284104 DIPICOLINIC ACID 1 5.11
CHEMBL277225 1 4.96
CHEMBL25644 1 4.49
CHEMBL24275 1 4.43
CHEMBL24351 1 4.38
CHEMBL416561 1 4.14
CHEMBL1439 TAZOBACTAM SODIUM 4.0 1 -
CHEMBL24878 1 -
CHEMBL277857 1 -
CHEMBL25613 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL25766 IC50 = 100.0 nM 7.00
CHEMBL24235 IC50 = 300.0 nM 6.52
CHEMBL26275 IC50 = 7600.0 nM 5.12
CHEMBL284104 DIPICOLINIC ACID IC50 = 7800.0 nM 5.11
CHEMBL277225 IC50 = 10900.0 nM 4.96
CHEMBL25644 IC50 = 32100.0 nM 4.49
CHEMBL24275 IC50 = 36900.0 nM 4.43
CHEMBL24351 IC50 = 41400.0 nM 4.38
CHEMBL416561 IC50 = 72300.0 nM 4.14
CHEMBL1439 TAZOBACTAM SODIUM IC50 > 200000.0 nM -
CHEMBL24878 IC50 > 200000.0 nM -
CHEMBL277857 IC50 > 200000.0 nM -
CHEMBL25613 IC50 > 200000.0 nM -