Assay Detail
Binding
CHEMBL712972
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Inhibitory activity against mouse macrophage metalloelastase (MME) using [3H]elastin as a substrate
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.86 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170601 | — | — | 1 | 8.32 |
| CHEMBL85030 | — | — | 1 | 8.31 |
| CHEMBL352526 | — | — | 1 | 8.22 |
| CHEMBL170040 | — | — | 1 | 8.16 |
| CHEMBL514138 | CGS-27023A | — | 1 | 8.11 |
| CHEMBL314064 | — | — | 1 | 8.02 |
| CHEMBL83685 | — | — | 1 | 7.89 |
| CHEMBL316169 | — | — | 1 | 7.89 |
| CHEMBL353451 | — | — | 1 | 7.82 |
| CHEMBL311336 | — | — | 1 | 7.80 |
| CHEMBL354192 | — | — | 1 | 7.80 |
| CHEMBL82827 | — | — | 1 | 7.51 |
| CHEMBL314204 | — | — | 1 | 7.46 |
| CHEMBL353941 | — | — | 1 | 7.43 |
| CHEMBL265476 | — | — | 1 | 7.17 |
| CHEMBL354635 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170601 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL85030 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL352526 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL170040 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL314064 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL83685 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL316169 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL353451 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL311336 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL354192 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL82827 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL314204 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL353941 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL265476 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL354635 | — | IC50 | > | 100.0 | nM | - |