Assay Detail
Binding
CHEMBL713108
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Binding affinity against Melatonin receptor 3 (MT3) of Syrian hamster brain and peripheral organs
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.95 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45 | MELATONIN | 4.0 | 1 | 7.56 |
| CHEMBL132405 | — | — | 1 | 7.28 |
| CHEMBL337838 | — | — | 1 | 6.62 |
| CHEMBL335427 | — | — | 1 | 6.59 |
| CHEMBL134435 | — | — | 1 | 6.31 |
| CHEMBL135072 | — | — | 1 | 5.97 |
| CHEMBL134330 | — | — | 1 | 5.90 |
| CHEMBL133775 | (R)-RAMELTEON | — | 1 | 5.64 |
| CHEMBL336507 | — | — | 1 | 5.59 |
| CHEMBL1218 | RAMELTEON | 4.0 | 1 | 5.58 |
| CHEMBL135108 | — | — | 1 | 5.32 |
| CHEMBL336536 | — | — | 1 | 5.27 |
| CHEMBL336960 | — | — | 1 | 5.23 |
| CHEMBL134102 | — | — | 1 | 5.22 |
| CHEMBL334851 | — | — | 1 | 5.21 |
| CHEMBL334736 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45 | MELATONIN | Ki | = | 27.6 | nM | 7.56 |
| CHEMBL132405 | — | Ki | = | 52.8 | nM | 7.28 |
| CHEMBL337838 | — | Ki | = | 237.0 | nM | 6.62 |
| CHEMBL335427 | — | Ki | = | 255.0 | nM | 6.59 |
| CHEMBL134435 | — | Ki | = | 492.0 | nM | 6.31 |
| CHEMBL135072 | — | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL134330 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL133775 | (R)-RAMELTEON | Ki | = | 2270.0 | nM | 5.64 |
| CHEMBL336507 | — | Ki | = | 2560.0 | nM | 5.59 |
| CHEMBL1218 | RAMELTEON | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL135108 | — | Ki | = | 4790.0 | nM | 5.32 |
| CHEMBL336536 | — | Ki | = | 5390.0 | nM | 5.27 |
| CHEMBL336960 | — | Ki | = | 5830.0 | nM | 5.23 |
| CHEMBL134102 | — | Ki | = | 5960.0 | nM | 5.22 |
| CHEMBL334851 | — | Ki | = | 6220.0 | nM | 5.21 |
| CHEMBL334736 | — | Ki | > | 10000.0 | nM | - |