Assay Detail
Functional
CHEMBL713192
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Tested for the agonistic activity against Metabotropic glutamate receptor 2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 2 (CHEMBL2851) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, molecular modeling, and biology of the 1-benzyl derivative of APDC-an apparent mGluR6 selective ligand
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.43 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8759 | EGLUMETAD | 2.0 | 1 | 7.46 |
| CHEMBL40086 | — | — | 1 | 6.52 |
| CHEMBL34453 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8759 | EGLUMETAD | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL40086 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL34453 | — | EC50 | = | 5000.0 | nM | 5.30 |