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Assay Detail

CHEMBL713253

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was tested for its anti-HIV activity in acutely infected MT-4 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MT4
Confidence 1 — Organism
Curated By Intermediate

Target

MT4 (CHEMBL388)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, anti-human immunodeficiency virus, and anti-hepatitis B virus activity of pyrimidine oxathiolane nucleosides
Choi W, Yeola S, Liotta DC, Schinazi RF, Painter GR, Davis M, St. Clair M, Furman PA
Bioorg Med Chem Lett (1993) 3 : 693 -696
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 5.42 5.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL89554 1 5.68
CHEMBL141 LAMIVUDINE 4.0 1 5.16
CHEMBL89357 1 -
CHEMBL330542 1 -
CHEMBL313807 1 -
CHEMBL90503 1 -
CHEMBL88360 1 -
CHEMBL327373 1 -
CHEMBL328799 1 -
CHEMBL330345 1 -
CHEMBL89447 1 -
CHEMBL89764 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL89554 EC50 = 2100.0 nM 5.68
CHEMBL141 LAMIVUDINE EC50 = 7000.0 nM 5.16
CHEMBL89357 EC50 > 200000.0 nM -
CHEMBL330542 EC50 > 200000.0 nM -
CHEMBL313807 EC50 > 200000.0 nM -
CHEMBL90503 EC50 > 200000.0 nM -
CHEMBL88360 EC50 > 200000.0 nM -
CHEMBL327373 EC50 > 200000.0 nM -
CHEMBL328799 EC50 > 200000.0 nM -
CHEMBL330345 EC50 > 200000.0 nM -
CHEMBL89447 EC50 > 200000.0 nM -
CHEMBL89764 EC50 > 200000.0 nM -