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Assay Detail

CHEMBL713254

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was tested in vitro for inhibition of cytopathic effect of HIV-1 3B in MT-4 lymphocytes
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol.
Kempf DJ, Codacovi L, Wang XC, Kohlbrenner WE, Wideburg NE, Saldivar A, Vasavanonda S, Marsh KC, Bryant P, Sham HL.
J Med Chem (1993) 36 : 320 -330
PubMed 8426362 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 5.24 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL322477 1 5.82
CHEMBL267793 1 5.82
CHEMBL323731 1 5.80
CHEMBL320322 1 5.77
CHEMBL112930 1 5.75
CHEMBL109992 1 5.70
CHEMBL331829 1 5.66
CHEMBL320743 1 5.64
CHEMBL320321 1 5.37
CHEMBL112412 1 5.16
CHEMBL330915 1 5.03
CHEMBL324916 1 5.02
CHEMBL113268 1 5.00
CHEMBL109220 1 5.00
CHEMBL112546 1 5.00
CHEMBL333611 1 4.85
CHEMBL322939 1 4.80
CHEMBL112578 1 4.77
CHEMBL110865 1 4.72
CHEMBL322964 1 4.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL322477 EC50 = 1500.0 nM 5.82
CHEMBL267793 EC50 = 1500.0 nM 5.82
CHEMBL323731 EC50 = 1600.0 nM 5.80
CHEMBL320322 EC50 = 1700.0 nM 5.77
CHEMBL112930 EC50 = 1800.0 nM 5.75
CHEMBL109992 EC50 = 2000.0 nM 5.70
CHEMBL331829 EC50 = 2200.0 nM 5.66
CHEMBL320743 EC50 = 2300.0 nM 5.64
CHEMBL320321 EC50 = 4300.0 nM 5.37
CHEMBL112412 EC50 = 6900.0 nM 5.16
CHEMBL330915 EC50 = 9400.0 nM 5.03
CHEMBL324916 EC50 = 9500.0 nM 5.02
CHEMBL113268 EC50 = 10000.0 nM 5.00
CHEMBL109220 EC50 = 10000.0 nM 5.00
CHEMBL112546 EC50 = 10000.0 nM 5.00
CHEMBL333611 EC50 = 14000.0 nM 4.85
CHEMBL322939 EC50 = 16000.0 nM 4.80
CHEMBL112578 EC50 = 17000.0 nM 4.77
CHEMBL110865 EC50 = 19000.0 nM 4.72
CHEMBL322964 EC50 = 88000.0 nM 4.06