Assay Detail
Functional
CHEMBL713255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro for inhibition of cytopathic effect of HIV-1 3B in MT-4 lymphocytes.
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 46 | 5.93 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331814 | — | — | 1 | 7.22 |
| CHEMBL113225 | — | — | 1 | 7.16 |
| CHEMBL109976 | — | — | 1 | 7.16 |
| CHEMBL83462 | — | — | 1 | 7.05 |
| CHEMBL314298 | — | — | 1 | 6.96 |
| CHEMBL113377 | — | — | 1 | 6.77 |
| CHEMBL115978 | — | — | 1 | 6.72 |
| CHEMBL324163 | — | — | 1 | 6.70 |
| CHEMBL269617 | — | — | 1 | 6.66 |
| CHEMBL112958 | — | — | 1 | 6.64 |
| CHEMBL112138 | — | — | 1 | 6.57 |
| CHEMBL323918 | — | — | 1 | 6.41 |
| CHEMBL322805 | — | — | 1 | 6.41 |
| CHEMBL322941 | — | — | 1 | 6.36 |
| CHEMBL112859 | — | — | 1 | 6.35 |
| CHEMBL111388 | — | — | 1 | 6.32 |
| CHEMBL114972 | — | — | 1 | 6.30 |
| CHEMBL326620 | — | — | 1 | 6.25 |
| CHEMBL109221 | — | — | 1 | 6.22 |
| CHEMBL322804 | — | — | 1 | 6.21 |
| CHEMBL324746 | — | — | 1 | 6.20 |
| CHEMBL113451 | — | — | 1 | 5.96 |
| CHEMBL323809 | — | — | 1 | 5.85 |
| CHEMBL113575 | — | — | 1 | 5.82 |
| CHEMBL432806 | — | — | 1 | 5.77 |
| CHEMBL113355 | — | — | 1 | 5.77 |
| CHEMBL333601 | — | — | 1 | 5.77 |
| CHEMBL112416 | — | — | 1 | 5.72 |
| CHEMBL324747 | — | — | 1 | 5.68 |
| CHEMBL109371 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331814 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL113225 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL109976 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL83462 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL314298 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL113377 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL115978 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL324163 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL269617 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL112958 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL112138 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL323918 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL322805 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL322941 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL112859 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL111388 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL114972 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL326620 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL109221 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL322804 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL324746 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL113451 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL323809 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL113575 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL113355 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL333601 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL432806 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL112416 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL324747 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL109371 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL113626 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL113627 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL323955 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL106486 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL333600 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL331363 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL114192 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL111957 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL112186 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL320126 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL263534 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL442010 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL113554 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL325731 | — | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL109699 | — | EC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL430891 | — | EC50 | = | - | nM | - |